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Quiz Prize Rules Current Rankings DIAGNOSIS:
Pituitary Stalk Interruption SyndromeThe MRI images show non-visualization of the pituitary stalk with an ectopic location of the neurohypophysis and hypoplasia of the adenohypophysis with an empty sella. These findings are highly suggestive of the pituitary stalk interruption syndrome. This patient was proved to have panhypopituitarism.
- Hypopituitarism is due to partial or complete deficiency of pituitary hormones which may derive from either pituitary or hypothalamic disease. Pituitary dwarfism is proportionate delay in growth due to growth hormone deficiency.
- Pituitary gland development is a complex multistep process involving fusion of adenohypophysis (Rathke’pouch, ectodermal) with neurohypophysis (neuroectodermal origin), occurring in early embryogenesis. The etiology is usually unknown. One possible explanation is trauma; involving transection of the stalk during breech delivery leading to an ectopic posterior pituitary.
- Infrequently a ssociated with midline anomalies, such as septo-optic dysplasia, Chiari-1, medial deviation of the internal carotids, micropenis and single central incisor.
References:
- MR imaging in children with Ectopic pituitary and anterior hypopituitarism J postgad med 1999;45:81-83
- Pituitary stalk interruption syndrome . Indian J. of paediatrics 2007;74;74-5
- GH deficiency with Ectopic neurohyphophysis- J. clin.endocrinology.metab.july1 1999;84(7)
- Ectopic posterior pituitary and periventricular heterotropia- AJNR J.of neuroradiology oct1 2002;23(9)
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PubMed References for Pituitary Stalk Interruption Syndrome
At any given time this link will provide references from Pubmed, including the most recent updates. Retrievals are designed to include articles available free and also Indian studies.
The following radiologists have answered this quiz correctly.
Names
Ajitsingh Jemalbhai Vadher
Alex Daniel
Ankit B Shah
C.V.Subbarao
Kabilan Chokkappan
Kanchan Gupta
Kiran Parmar
Kumaran. R
Muddassir Rashid
P Senthilkumar
Rajal Choudhary
Rajneesh Galwa
Ram Prakash Galwa
SP Manickam
Suresh Thakur
Trupti Dabholkar
V.Sujatha
Vasanthakumar V
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